Design Pad (dPad)

The Design Pad has a choice of Building Blocks (BBs) to choose from including: Fc, Fab, VHH, scFv, scFab, xFab, Mutein, Mini-protein, De Novo, Reagent and Tags.

Creating New Formats

The BioGlyph dPad was designed to create a seamless experience where scientists can focus purely on the design of biologic formats, while the BG technology manages format registration in the backend. This approach helps organizations build their own internal format libraries while maintaining a universal language system that accommodates a format agnostic approach.

Core Concepts

Ease of use by connecting Building Blocks

The dPad platform is designed to simplify the process by enabling users to connect Building Blocks via proximity. This design minimizes mouse clicks, reducing the risk of ergonomic strain. Users can drag the Building Blocks from a pre-curated collection of 10, initially selected by BioGlyph, and drop them close to one another, allowing linkage that mirrors genetic fusion.

Controlled connectivity of Building Blocks

From a scientific standpoint, not all 10 building blocks in our library can be interconnected, largely due to the presence of the Fc Building Block in both homodimeric and heterodimeric forms. The Fc plays a pivotal role in constructing multispecific antibody formats by guiding chain pairing, which is essential for generating format diversity. The decision to use a homodimer or heterodimer Fc depends on the format symmetry. If the format is the mirror image for shape (components and Building Blocks) and color (sequence/target) across the Y-axis, splitting through the Fc, the homodimer is the appropriate choice. Conversely, if it is asymmetrical, the heterodimer should be used. The smart features of the dPAD will ensure this prior to the saving of new formats in the organization’s library.

Format uniqueness

A key concept developed by Bioglyph that allows scientists to establish a universal library of biologic formats across multiple projects. When a format is reused in different projects, it retains the same identifier—no new ID or alias is created—ensuring consistency and traceability.